Broad-spectrum caspase inhibitors: from myth to reality?

Intracellular angiotensin II: from myth to reality?

Introduction The importance of the renin-angiotensin system (RAS) was first recognised in 1934. 1 Extensive research started in the mid-1950s by Skeggs and co-workers, who identified the transformation of a decapeptide into an octapeptide by a factor from horse blood plasma. 2,3 At that time, the two pep-tides were called hypertensin I and hypertensin II. In the same year, the laboratory synthe...

The future of antivirals: broad-spectrum inhibitors.

PURPOSE OF REVIEW Potent antivirals are successfully used for the treatment of infections with herpesviruses, hepatitis B and C viruses, HIV, and with some success for influenza viruses. However, no selective inhibitors are available for a multitude of medically important viruses, most of which are (re-)emerging RNA viruses. As it is impossible to develop drugs against each of these viruses, br...

Largazole: from discovery to broad-spectrum therapy.

The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transformed cells. The intriguing structure and biological activity of largazole have ...

The future of antihypertensive treatment: from myth to imminent reality.

Internet Protocol over Wireless Sensor Networks, from Myth to Reality

Internet Protocol (IP) is a standard network layer protocol of the Internet architecture, allowing communication among heterogeneous networks. For a given network to be accessible from the Internet it must have a router that complies with this protocol. Wireless sensor networks have many smart sensing nodes with computational, communication and sensing capabilities. Such smart sensors cooperate...